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Discussion forum - 49th ERA-EDTA Congress
    Topic - Cell signalling / Pathophysiology

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Poster: 35
Visits: 1060
Title: Dimerization of the calcium-sensing receptor and response to cinacalcet HCl
Authors: Hansjrg Rothe , Warren B ShapiroMarkus Ketteler
Centre: Klinikum Coburg

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DIMERIZATION OF THE CALCIUM-SENSING RECEPTOR AND RESPONSE TO CINACALCET HCL

Hansjörg Rothe
Thread initiator
Subspeciality Pharmacogenetics
Reg: 5/8/2012 12:28:00 AM

 Comment# 1

I find it always intriguing how bench research findings may actually be reflected by clinical studies - in this case the recently established property of the CaSR to form dimers and oligomeric mosaics, and our finding that heterozygotes and homozygotes for a certain polymorphism respond differently in the first 2 hours after administration of cinacalcet. Noteworthy, already in 2002 when Bill Goodman published the first dose-response curve with just 6 patients, one of them went up with his PTH instead of down... One out of 6 is a good estimate, in a study in Innsbruck we found about 10 of dialysis patients to be heterozygote for this polymorphism
Comment added on 6/5/2012 11:24:00 AM 
     
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Poster most viewed in this topic
Poster: 35
Visits: 1060
Title: Dimerization of the calcium-sensing receptor and response to cinacalcet HCl
Authors: Hansjrg Rothe , Warren B ShapiroMarkus Ketteler
Centre: Klinikum Coburg


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